Experimental chloroquine myopathy.

Chloroquine myopathy.

Expression of autophagy-associated genes in skeletal muscle: an experimental model of chloroquine-induced myopathy.

OBJECTIVE Chloroquine modulates autophagocytic protein degradation in the lysosome system, thereby inducing the formation of rimmed vacuoles consisting of autophagosomes and autolysosomes in skeletal muscle. The goal of this study was to investigate the contribution of the lysosomal system, particularly autophagosome formation (an autophagic process) at the molecular level, to the abnormal accu...

Severe, reversible dysphagia from chloroquine and hydroxychloroquine myopathy.

An 89-year-old man presented with a 3-year history of progressive oropharyngeal dysphagia with both solids and liquids. He had no fatigability of chewing or swallowing but had difficulty propelling the bolus back to his posterior pharynx. His dysphagia was profound, and he had lost over 20 pounds of weight. He twice developed aspiration pneumonia. He was otherwise in good health and had longsta...

Clinical and experimental skeletal muscle alcoholic myopathy.

Musculoskeletal symptoms are frequent in chronic alcohol abusers, but only relatively recently has a search been made for the pathological basis of these complaints. A prospective study of 150 unselected patients admitted with various forms of alcohol abuse, showed that on quadriceps muscle biopsy two-thirds of the patients had significant and specific atrophy of the type IIB (anaerobic, fast-t...

Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy

Several myopathies are associated with defects in autophagic and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the lysosome and what significance this process has for muscle cells. We have established a Drosophila melanogaster model to study glycogen autophagy in skeletal muscles, using chloroquine (CQ) to simulate a vacuolar myopathy that is completely d...